The North America Oligonucleotide Synthesis market is expected to reach US$ $ 1,541.03 Mn in 2027 from US$ 609.90 Mn in 2018. The market is estimated to grow with a CAGR of 11.2% from 2019-2027.
The growth of the North America Oligonucleotide Synthesis market is driven by several key factors, including increasing investments in pharmaceutical and biotechnology sectors, substantial government funding, and the rising number of market participants focusing on oligonucleotide synthesis. These elements are expected to significantly boost market expansion across the region during the forecast period.
Oligonucleotides play a vital role in various biological applications as sequence-specific binding agents that help detect specific DNA sequences. Synthetic oligonucleotides—short, single-stranded DNA fragments—are widely utilized in disease diagnostics, biotechnology research, therapeutics, forensics, and drug discovery. In particular, they are instrumental in diagnosing genetic disorders. Oligonucleotide probes can detect single base-pair mutations in the human genome. For example, sickle cell anemia, caused by a single nucleotide transversion (A→T) in the β-globin gene, can be analyzed using labeled oligonucleotide probes under stringent hybridization conditions.
Researchers are also leveraging oligonucleotides to support greener and more efficient chemical synthesis methods. By assembling short oligonucleotide sequences into longer synthetic gene fragments, scientists can program microbial cells—such as bacteria or yeast—to produce specific enzymes or therapeutic proteins.
Additionally, oligonucleotides have opened new avenues in therapeutic development. They enable precise targeting, modulation, or silencing of malfunctioning genes. Companies like Ionis Pharmaceuticals have pioneered antisense oligonucleotide (ASO) therapies, underscoring the promising potential of these molecules in treating a wide range of diseases.
Recent clinical trial activities in Canada further support North America Oligonucleotide Synthesis market growth. For instance, in January 2019, a Phase 3 trial was launched to evaluate the efficacy of RG6042 (formerly IONIS-HTTRx), an antisense oligonucleotide therapy initially developed by Ionis Pharmaceuticals and later acquired by Roche. The therapy targets and degrades mutant huntingtin protein (mHTT), the primary cause of Huntington’s disease. This trial, conducted across six sites in five Canadian provinces, highlights the growing clinical adoption of oligonucleotide-based treatments.
Within North America, the United States is expected to dominate the market due to substantial funding and investment in both the commercial and academic sectors. The focus on gene synthesis technologies for precision medicine and other therapeutic applications positions the U.S. as a major contributor to regional market growth. Considering these factors, the country is projected to hold the largest market share in North America over the forecast period.
North America Oligonucleotide Synthesis Market Segmentation
North America Oligonucleotide Synthesis Market By Product
- Synthesized Oligonucleotides
- Primers
- Probes
- Large-Scale Synthesis
- Others
- Reagents
- Equipment
North America Oligonucleotide Synthesis Market By Application
- Research
- Diagnostics
- Therapeutics
North America Oligonucleotide Synthesis Market By End User
- Academic Research Institutes
- Pharmaceutical & Biotechnology Companies
- Diagnostic Laboratories
- Other End Users
North America Oligonucleotide Synthesis Market By Geography
- North America
- US
- Canada
- Mexico
North America Oligonucleotide Synthesis Market Company Profiles
- Thermo Fisher Scientific Inc.
- GenScript
- Molecular Assemblies
- Twist Biosciences
- Evonetix
- DNA Script
- Nuclera Nucleics
- Camena Bioscience
- Synthomics
- Ansa Biotechnologies
North America Oligonucleotide Synthesis Market Strategic Insights
Strategic insights for the North America Oligonucleotide Synthesis provides data-driven analysis of the industry landscape, including current trends, key players, and regional nuances. These insights offer actionable recommendations, enabling readers to differentiate themselves from competitors by identifying untapped segments or developing unique value propositions. Leveraging data analytics, these insights help industry players anticipate the market shifts, whether investors, manufacturers, or other stakeholders. A future-oriented perspective is essential, helping stakeholders anticipate market shifts and position themselves for long-term success in this dynamic region. Ultimately, effective strategic insights empower readers to make informed decisions that drive profitability and achieve their business objectives within the market.
North America Oligonucleotide Synthesis Market Regional Insights
The geographic scope of the North America Oligonucleotide Synthesis refers to the specific areas in which a business operates and competes. Understanding local distinctions, such as diverse consumer preferences (e.g., demand for specific plug types or battery backup durations), varying economic conditions, and regulatory environments, is crucial for tailoring strategies to specific markets. Businesses can expand their reach by identifying underserved areas or adapting their offerings to meet local demands. A clear market focus allows for more effective resource allocation, targeted marketing campaigns, and better positioning against local competitors, ultimately driving growth in those targeted areas.
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Author’s Bio:
Suryakant Gadekar
Senior Market Research Expert at Business Market Insights
